Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis.

We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents.This new compound is effective against Gram positive microorganisms, with a potency similar to that of ceftriaxone, a cephalosporin widely used in clinics and taken as

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Cytodiagnosis of myxoid adrenocortical carcinoma and role of immunocytochemistry to differentiate it from renal cell carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy LIGHT TREATMENT and cytodiagnosis of this tumor is not routinely encountered by a cytopathologist.Here, we report a case of ACC initially diagnosed by computed tomography (CT)-guided fine needle aspiration cytology (FNAC) with the help of immunocytochemistry.A 48-year-old lady presented with flank

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Advance care planning after hospital discharge: qualitative analysis of facilitators and barriers from patient interviews

Abstract Background Patients who engage in Advance Care Planning (ACP) are more likely to get care consistent with their values.We sought to determine the barriers and facilitators to ACP engagement after discharge from hospital.Methods Prior to discharge from hospital eligible patients received a standardized conversation about prognosis and ACP.E

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